Southwest Florida Region Southwest Region of Florida Southwest Florida includes the Lee Island Coast with the beautiful Gulf Coast beaches to the natural Everglades to Lake Okeechobee to the Florida Keys. Includes Monroe, Collier, Hendry, Lee, Glades Counties Businesses & Articles in this Region Popular TopicsArts Attractions Books & Literature Business Community Events & Festivals Food & Drink Health Home & Garden Lifestyle Nature Pets Places to Stay Real Estate Retirement Shopping